内容摘要：A few weeks before the CVS in Herscher, Illinois, closed in early March, farmer Kip Harms picked up a muscle relaxer for a back injury. He asked the staff if he could take it with Tylenol.

A few weeks before the CVS in Herscher, Illinois, closed in early March, farmer Kip Harms picked up a muscle relaxer for a back injury. He asked the staff if he could take it with Tylenol.

, which triggers immediate destruction from the human immune system. Next came three-gene “knockouts,” to remove other immune-triggering red flags. Now the company is focusing on 10 gene edits — deleted pig genes and added human ones that together lessen risk of rejection and blood clots plus limit organ size.They clone pigs with those alterations, similar to how Dolly the sheep was created.

Twice a week, slaughterhouses ship Revivicor hundreds of eggs retrieved from sow ovaries. Working in the dark with the light-sensitive eggs, scientists peer through a microscope while suctioning out the maternal DNA. Then they slip in the genetic modifications.A worker at United Therapeutics’ designated pathogen-free facility in Christiansburg, Va., on May 29, 2024 retrives a UV sterilized item from behind a protected barrier within the facility. (AP Photo/Shelby Lum)A worker at United Therapeutics’ designated pathogen-free facility in Christiansburg, Va., on May 29, 2024 retrives a UV sterilized item from behind a protected barrier within the facility. (AP Photo/Shelby Lum)

“Tuck it in nice and smooth,” murmurs senior researcher Lori Sorrells, pushing to just the right spot without rupturing the egg. Mild electric shocks fuse in the new DNA and activate embryo growth.Ayares, a molecular geneticist who heads Revivicor and helped create the world’s first cloned pigs in 2000, says the technique is “like playing two video games at the same time,” holding the egg in place with one hand and manipulating it with the other. The company’s first modified pig, the

single gene knockout, now is bred instead of cloned. If xenotransplantation eventually works, other pigs with the desired gene combinations would be, too.

Hours later, embryos are carried to the research farm in a handheld incubator and implanted into waiting sows.Matt Metzger, a Marine Corps combat veteran, harvests and places Psilocybe cubensis mushrooms into a dehydrator to prepare for microdosing Wednesday, March 26, 2025, in Olympia, Wash. (AP Photo/Lindsey Wasson)

Matt Metzger, a Marine Corps combat veteran, harvests and places Psilocybe cubensis mushrooms into a dehydrator to prepare for microdosing Wednesday, March 26, 2025, in Olympia, Wash. (AP Photo/Lindsey Wasson)One small study suggests any psychological benefits come from users’ expectations — the placebo effect. But the science is still new and research is ongoing.

The substances are illegal in most places, but the wave of scientific research focused on the benefits of supervised hallucinatory experiences has spurredto legalize psychedelic therapy. Further opening the door to microdosing, a handful of cities have officially directed police to make psychedelics a low priority for enforcement.